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Very high doses of zinc may actually weaken immune function. High doses of zinc may also lower HDL ("good") cholesterol and raise LDL ("bad") cholesterol. Zinc is required for proper healing and studies have indicated that being deficient in zinc can slow the wound healing process. Acne is associated with low zinc levels, according to this report on innovative uses for zinc in dermatology. Different Forms Of Zinc Supplements Similar to MT, intestinal zinc transporters are not only required for the maintenance of enterocyte zinc homeostasis, but are also decisive for zinc absorption ( Figure 3). The main intestinal zinc importer ZIP4 is essential for zinc absorption. This is demonstrated by the zinc malabsorption disease acrodermatitis enteropathica, originating from different mutations in the gene encoding human ZIP4 [ 81, 82, 126, 127]. ZIP4 is regulated by dietary zinc in a transcriptional, translational, and post-translational manner [ 128]. Moreover, surface localization of enterocyte ZIP4 is regulated by cytoplasmic zinc [ 129]. Under zinc deficiency, zip4 mRNA is stabilized [ 127, 130, 131] and the protein accumulates at the apical plasma membrane result in elevated zinc uptake [ 129, 132]. Zinc repletion results in endocytosis of the protein [ 129], and ubiquitin-mediated degradation at even higher zinc concentrations [ 133, 134], while transcription remains unaltered [ 86].
Sinclair S. Male infertility: nutritional and environmental considerations. Altern Med Rev. 2000;5(1):28-38. Zinc can be challenging for your body to absorb on its own, so if you take a supplement, it is often attached to a chelate. This makes it easier for your body to absorb. It is possible to have too much zinc in your body if you supplement too much. Signs that you may have too much zinc include diarrhea, nausea, stomach cramps. It is an essential cofactor in enzymes involved in synthesising various bone matrix cells and plays a role in bone deposition and resorption. In addition to this, it plays a structural role in the bone matrix itself. The hydroxyapatite crystals, making up the bone mineral, contain a zinc-fluoride complex and zinc is needed for osteoblastic (bone formation) activity. Zinc deficiency decreases the activity of matrix proteins, type 1 collagen and alkaline phosphatase decreasing calcium and phosphorus accumulation. Therefore, zinc deficiency may become a risk factor for poor extra cellular matrix calcification.van Leeuwen R, Boekhoorn S, Vingerling JR, et al. Dietary intake of antioxidants and risk of age-related macular degeneration. JAMA. 2005;294:3101-7. Now you know the importance of zinc in the body, you can maintain a healthy zinc level. Whether with your diet or with a Zinc Glycinate supplement, you know why it is vital for day-to-day bodily functions. Penicillamine -- This medication, used to treat Wilson's disease (where excess copper builds up in the brain, liver, kidney, and eyes) and rheumatoid arthritis, decreases the levels of zinc in your blood. Grahn BH, Paterson PG, Gottschall-Pass KT, Zhang Z. Zinc and the eye. J Am Coll Nutr. 2001;20(2 Suppl):106-118.
Dosage of zinc, as zinc intake in dosages is increased, percentage absorption decreases probably due to the saturation of the transport mechanisms. Fractional zinc absorption preferentially depends on zinc intake, as its efficiency declines with increased zinc consumption [ 7, 8, 32]. Additionally, the zinc species influences its intestinal absorption, which is of particular relevance for zinc supplements (for details refer to Reference [ 30]).Zinc reduces the amount of copper your body absorbs, and high doses of zinc can cause a copper deficiency. For that reason, many doctors recommend that you take 2 mg of copper along with a zinc supplement. There is a very fine balance between zinc and copper during intestinal absorption. Zinc reduces the amount of copper your body absorbs because copper competes with zinc to bind with metallothionein, the binding protein that brings zinc into the intestinal cells. The ratio of zinc: copper is arguably more important than the concentration of either copper or zinc, and a common problem is excessive copper in water from copper pipes or copper cookware. Generally, zinc should not be taken on an empty stomach (as it can result in nausea), should be taken with an animal protein meal, away from cereals and taken in conservative doses to increase absorption.
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